The role of cGMP signalling in regulating life cycle progression of Plasmodium
نویسندگان
چکیده
The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented.
منابع مشابه
The role of the cGMP-dependent protein kinase in development of the malaria parasite
The life cycle of the malaria parasite Plasmodium is complex with distinct phases occurring in the human host and the mosquito vector. Proliferation of asexual parasites within blood cells leads to pathology whereas a distinct sexual stage is required to mediate transmission to the insect. There is a surprising lack of information about how progression of the life cycle is controlled. By analog...
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